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Hilton Jacksonville At Mayo Clinic

4.5 star property
VIP Access

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Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Lobby
Lake view
Lobby
Terrace/patio

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Parking included
  • Free Wi-Fi
  • Restaurant
  • Air-conditioning
  • Gym

Explore the area

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4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪32 min drive‬
VIP Access
Curated for quality and service, VIP Access stays consistently receive our highest guest ratings.
  • Expect exceptional service
  • Extra savings and perks for BONUS+ members
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Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

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View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed (Zero Count)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds

10.0 out of 10
Exceptional
(19 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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About this property

Hilton Jacksonville At Mayo Clinic

Luxury hotel with free local area shuttle and fitness centre
Along with an outdoor pool, this smoke-free hotel has a restaurant and a fitness centre. Free WiFi in public areas, free self parking and a free area shuttle are also provided. Other amenities include a bar/lounge, conference space and concierge services.
Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottles of water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include baths or showers and hairdryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include telephones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and an iron/ironing board. Housekeeping is provided on a daily basis.

Recreational amenities at the hotel include an outdoor pool and a fitness centre.

Children aged under 16 years old are not allowed in the swimming pool without adult supervision. Guests aged under 16 years old are not allowed in the fitness facility.

During your stay at Hilton Jacksonville At Mayo Clinic, you'll be within walking distance of Mayo Clinic Florida. Free WiFi in public areas, free self-parking and a free area shuttle are available.
  • Free Wi-Fi (speed: 25+ Mbps)
  • Free self-parking
  • Enjoy American cuisine while dining at Coastal Kitchen
  • Buffet breakfast served daily for a fee
  • Take a swim in the outdoor pool
  • Services include dry cleaning/laundry, a concierge and a porter
  • On-site recreation includes a gym
  • Just a 2-minute drive from Mayo Clinic Florida and 8 minutes from St. Johns Town Center
  • Free local-area shuttle service
Hilton Jacksonville At Mayo Clinic offers its guests an outdoor pool and a fitness centre. There's a restaurant on site. You can enjoy a drink at the bar/lounge. Public spaces have free WiFi.

Business amenities include 12 meeting rooms and coworking spaces. Event space at this hotel measures 20000 square feet (1858 square metres) and includes conference space. The luxury Hilton Jacksonville At Mayo Clinic also features concierge services, laundry facilities, and dry cleaning/laundry services. A free area shuttle within 350 yards is available. Self parking is free.

This 4.5-star Jacksonville hotel is smoke free.

For a fee, guests can enjoy a buffet breakfast daily from 6:00 AM to 10:30 AM.
Coastal Kitchen – This restaurant specialises in American cuisine and serves breakfast, lunch and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar – On-site cocktail bar. Open daily.
Late-night fare is available from room service (during limited hours).

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transport

  • Electric car charging station on site
  • Free area shuttle up to 350 yards
  • Free uncovered self parking on site
  • Limited on-site self parking

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room cot
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoke-free property
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free cot
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM
Contactless check-out
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Kids stay free! Up to 2 children aged 18 years old and younger stay free per registered adult when using existing bedding.
  • Rollaway/extra beds are available for USD 50.00 per night.
  • Free cots (infant beds)!

Payment types at the property

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Breakage deposit: USD 100 per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorise the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector
Guests arriving after 11:00 PM must make advance arrangements by contacting the property using the information on the booking confirmation. Front desk staff will greet guests on arrival at the property. The credit card used when booking the reservation must be presented by the cardholder at check-in along with matching photo ID. Other arrangements must be coordinated with the property prior to arrival.
If you cancel your booking, you'll be subject to the host's cancellation policy. In accordance with EU regulations about consumer rights, property booking services are not subject to the right of withdrawal.

We should mention

  • Pool access available from 8:00 AM to 10:00 PM
  • Up to 2 children aged 18 years old and younger stay free per registered adult in the same room as the parent or guardian when using existing bedding.
  • Registered guests are the only ones allowed to be in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 92 out of 111 reviews
Rating 8 - Good. 9 out of 111 reviews
Rating 6 - Okay. 4 out of 111 reviews
Rating 4 - Poor. 3 out of 111 reviews
Rating 2 - Terrible. 3 out of 111 reviews

10/10

Cleanliness

9.8/10

Staff & service

9.6/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

JoAnn

Travelled with family
Liked: Cleanliness, staff & service, amenities
The overall experience was excellent. The room was well maintained and clean. The staff were extremely helpful and accommodating. The experience was so positive that earlier today I booked a stay at a Hilton in the city of a conference I will be attending in the Spring.
Stayed 2 nights in Jan 2026

10/10 Excellent

Schylea

Travelled with family, Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, friendly staff close to Mayo Clinic.
Stayed 2 nights in Jan 2026

10/10 Excellent

Melody

Business traveller
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Everything was exceptional!
Stayed 2 nights in Jan 2026

10/10 Excellent

Catherine

Business traveller
Liked: Cleanliness, staff & service, amenities
Beautiful hotel! Very comfortable beds. Spotless!! Definitely recommend. A+++++
Stayed 1 night in Jan 2026

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities
Room was spotless, amenities were great, and staff was super nice!
Stayed 5 nights in Dec 2025

10/10 Excellent

Keyante

Travelled with family, Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful shuttle to Mayo!
Stayed 2 nights in Dec 2025

10/10 Excellent

Nancy

Travelled with partner, Travelled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Just a short overnight stay to attend NYE event. Spent a short time at the very nice bar. Will stay again.
Stayed 1 night in Dec 2025

10/10 Excellent

Catesha

Liked: Cleanliness, amenities, property conditions & facilities
Very clean
Stayed 1 night in Dec 2025

10/10 Excellent

Julie

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, clean, great atmosphere, very nice staff!
Stayed 2 nights in Dec 2025

10/10 Excellent

anjillica

Liked: Cleanliness, amenities, property conditions & facilities
Very nice enjoyed visiting
Stayed 1 night in Dec 2025

8/10 Good

Tristan

Liked: Cleanliness, staff & service, amenities
The staff were courteous, the amenities fantastic. Only problem was a clump of hair from a previous guest found in the shower.
Stayed 1 night in Dec 2025

8/10 Good

Lee

Business traveller
Liked: Cleanliness, staff & service, amenities
Clean room.
Stayed 1 night in Dec 2025

8/10 Good

Gregory

Stayed 5 nights in Nov 2025

10/10 Excellent

Robert

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Most everything
Stayed 4 nights in Dec 2025

10/10 Excellent

Stanislav

Liked: Cleanliness, property conditions & facilities
Cleanliness
Stayed 1 night in Dec 2025

10/10 Excellent

DeAnna

Stayed 2 nights in Nov 2025

10/10 Excellent

Jose

Liked: Cleanliness, staff & service, amenities
Staff was courteous. Room was clean and comfortable. Everything looked brand new. Very clean. Beautiful hotel. Will definitely go back.
Stayed 2 nights in Dec 2025

10/10 Excellent

Alan

Stayed 3 nights in Dec 2025

10/10 Excellent

Christy

Liked: Cleanliness, amenities, property conditions & facilities
Staff courteous. Room great
Stayed 1 night in Dec 2025

10/10 Excellent

Sarah

Stayed 1 night in Dec 2025

10/10 Excellent

Beneishia

Stayed 1 night in Dec 2025

10/10 Excellent

Donald

Stayed 2 nights in Dec 2025

10/10 Excellent

Jo-Ann

Liked: Cleanliness, staff & service, amenities
Staff was friendly. Room was clean. Little wait at checkin. Bed was great!
Stayed 1 night in Dec 2025

10/10 Excellent

Shirley

Stayed 5 nights in Dec 2025

10/10 Excellent

Roselyn

Travelled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property and staff was great
Stayed 2 nights in Nov 2025