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Hilton Jacksonville At Mayo Clinic

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Breakfast, lunch, dinner served; American cuisine
Lake view
Lobby
Terrace/patio
Lobby

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Free Wi-Fi
  • Restaurant
  • Air-conditioning
  • Gym

Explore the area

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4745 Transformation Way, Jacksonville, FL, 32224
  • Place, University of North Florida
    ‪6 min drive‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪37 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed

8.8 out of 10
Excellent
(6 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(22 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout curtains, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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About this property

Hilton Jacksonville At Mayo Clinic

Along with an outdoor pool, this smoke-free hotel has a restaurant and a fitness centre. Free WiFi in public areas and a free area shuttle are also provided. Additionally, a bar/lounge, self parking and conference space are on-site.
Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottles of water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include baths or showers and hairdryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include telephones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and an iron/ironing board. Housekeeping is provided on a daily basis.

Recreational amenities at the hotel include an outdoor pool and a fitness centre.

Children aged under 16 years old are not allowed in the swimming pool without adult supervision. Guests aged under 21 years old are not allowed in the fitness facility.

During your stay at Hilton Jacksonville At Mayo Clinic, you'll be within walking distance of Mayo Clinic Florida. Enjoy features like free WiFi in public areas and a free area shuttle, plus an outdoor pool.
  • Free Wi-Fi (speed: 25+ Mbps)
  • Enjoy American cuisine while dining at Coastal Kitchen
  • Buffet breakfast served daily for a fee
  • Self-parking available for a fee
  • Take a swim in the outdoor pool
  • Services include dry cleaning/laundry, a concierge and a porter
  • On-site recreation includes a gym
  • Just a 2-minute drive from Mayo Clinic Florida and 8 minutes from St. Johns Town Center
  • Free local-area shuttle service
Hilton Jacksonville At Mayo Clinic offers its guests an outdoor pool and a fitness centre. There's a restaurant on site. You can enjoy a drink at the bar/lounge. Public spaces have free WiFi.

Business amenities include 12 meeting rooms and coworking spaces. Event space at this hotel measures 20000 square feet (1858 square metres) and includes conference space. The luxury Hilton Jacksonville At Mayo Clinic also features concierge services, laundry facilities, and dry cleaning/laundry services. A free area shuttle within 350 yards is available. Parking is available for a fee.

This 4.5-star Jacksonville hotel is smoke free.

For a fee, guests can enjoy a buffet breakfast daily from 6:00 AM to 10:30 AM.
Coastal Kitchen – This restaurant specialises in American cuisine and serves breakfast, lunch and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar – On-site cocktail bar. Open daily.
Late-night fare is available from room service (during limited hours).

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transport

  • Electric car charging station on site
  • Free area shuttle up to 350 yards
  • Uncovered parking on site (USD 12 per night)
  • Limited on-site self parking

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 30 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room cot
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoke-free property
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free cot
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM
Contactless check-out
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Kids stay free! Up to 2 children aged 18 years old and younger stay free per registered adult when using existing bedding.
  • Rollaway/extra beds are available for USD 50.00 per night.
  • Free cots (infant beds)!

Payment types at the property

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Breakage deposit: USD 100 per day

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults and USD 15 to 30 for children
  • Uncovered self-parking fee: USD 12.00 per night
  • Rollaway bed fee: USD 50.00 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorise the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher and a smoke detector
Guests arriving after 11:00 PM must make advance arrangements by contacting the property using the information on the booking confirmation. Front desk staff will greet guests on arrival at the property. The credit card used when booking the reservation must be presented by the cardholder at check-in along with matching photo ID. Other arrangements must be coordinated with the property prior to arrival.
If you cancel your booking, you'll be subject to the host's cancellation policy. In accordance with EU regulations about consumer rights, property booking services are not subject to the right of withdrawal.

We should mention

  • Pool access available from 8:00 AM to 10:00 PM
  • Up to 2 children aged 18 years old and younger stay free per registered adult in the same room as the parent or guardian when using existing bedding.
  • Registered guests are the only ones allowed to be in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 177 out of 221 reviews
Rating 8 - Good. 22 out of 221 reviews
Rating 6 - Okay. 11 out of 221 reviews
Rating 4 - Poor. 6 out of 221 reviews
Rating 2 - Terrible. 5 out of 221 reviews

9.8/10

Cleanliness

9.6/10

Staff & service

9.4/10

Amenities

9.8/10

Property conditions & facilities

Reviews

10/10 Excellent

Sharika

Travelled with family, Travelled with group
Liked: Cleanliness, staff & service, amenities
Everything was GREAT!!!
Stayed 1 night in Jan 2026

4/10 Poor

Lynn, Miramar Beach

Stayed 3 nights in Feb 2026

10/10 Excellent

Erin

Wonderful!
Stayed 1 night in Feb 2026

10/10 Excellent

Roberto

Stayed 1 night in Jan 2026

10/10 Excellent

Maria Ines, Guatemala

Liked: Cleanliness, amenities, property conditions & facilities
Good restaurant, convenient location for Mayo Clinic, easy parking.
Stayed 3 nights in Jan 2026

10/10 Excellent

milad

Stayed 2 nights in Jan 2026

8/10 Good

Vicki

Stayed 3 nights in Jan 2026

10/10 Excellent

Samuel

Nice room
Stayed 2 nights in Oct 2025

10/10 Excellent

Tonya, Bellevue

Stayed 1 night in Jan 2026

10/10 Excellent

Mohsin

Travelled with family
Liked: Cleanliness, amenities, property conditions & facilities
Newly constructed, very clean and well maintained. Great staff. Highly recommend.
Stayed 1 night in Jan 2026

10/10 Excellent

Daisy

Liked: Cleanliness, amenities, property conditions & facilities
Loved this hotel! Great location - friendly staff- yummy food and drinks at Coastal restaurant- hire and rooms are so nice and clean - pool and gym area were a plus! Coffee spot and shuttle also nice to have available.
Stayed 3 nights in Jan 2026

10/10 Excellent

Herman

Travelled with family, Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Spotless
Stayed 1 night in Jan 2026

10/10 Excellent

Diane

Stayed 10 nights in Jan 2026

10/10 Excellent

Samuel

Stayed 4 nights in Jan 2026

10/10 Excellent

Melissa

The rooms were clean. Bar staff were wonderful, great personalities.
Stayed 3 nights in Jan 2026

10/10 Excellent

Shaunte

Travelled with family
Liked: Cleanliness, staff & service, amenities
The staff and hotel were wonderful!
Stayed 1 night in Jan 2026

10/10 Excellent

Karlee

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
N/A
Stayed 1 night in Jan 2026

10/10 Excellent

COLIN

Stayed 1 night in Jan 2026

10/10 Excellent

Christian

Travelled with family
Liked: Cleanliness, property conditions & facilities
The hotel looks like brand new! Modern and clean.
Stayed 1 night in Jan 2026

10/10 Excellent

Gonzalo

Excellent stay from start to finish. Very nice overall.
Stayed 1 night in Jan 2026

10/10 Excellent

Kayla, Jacksonville

Stayed 2 nights in Jan 2026

10/10 Excellent

Andrea

Stayed 1 night in Jan 2026

10/10 Excellent

JoAnn

Travelled with family
Liked: Cleanliness, staff & service, amenities
The overall experience was excellent. The room was well maintained and clean. The staff were extremely helpful and accommodating. The experience was so positive that earlier today I booked a stay at a Hilton in the city of a conference I will be attending in the Spring.
Stayed 2 nights in Jan 2026

10/10 Excellent

Mark

Stayed 4 nights in Jan 2026

10/10 Excellent

Schylea

Travelled with family, Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, friendly staff close to Mayo Clinic.
Stayed 2 nights in Jan 2026