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21C Museum Hotel St Louis

4.5 star property

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Interior
Dining
Billiards
Free toiletries, hair dryer, bathrobes, towels
Business centre

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, Busch Stadium
    ‪14 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(76 reviews)
  • 29 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(22 reviews)
  • 39 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 22 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Loft, 2 Queen Beds

  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, Accessible (Accessible)

  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (Library)

  • 68 sq m
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Suite, 1 King Bed

  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About this property

21C Museum Hotel St Louis

Luxury hotel with fitness centre and steam room
This smoke-free hotel features an indoor pool, a restaurant and a fitness centre. WiFi in public areas is free. Additionally, a bar/lounge, a steam room and a coffee shop/cafe are on-site. Change of towels is available on request
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and a safe. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries and hairdryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs and telephones. Additionally, rooms include complimentary bottles of water and an iron/ironing board. Change of towels and change of bedsheets can be requested. Housekeeping is provided on a daily basis.

Recreational amenities at the hotel include an indoor pool, a steam room and a fitness centre.
Guests can pamper themselves by indulging in the on-site spa services. Services include massages.
Our customers tell us they can't get enough of 21C Museum Hotel St Louis 's great location. During your stay, you're just a quick walk from City Museum. Enjoy features like free WiFi in public areas, plus an indoor pool and a restaurant.
  • Free WiFi
  • Drinking and dining options include a coffee shop, a restaurant and a bar/lounge
  • Cooked-to-order breakfast served daily for a fee
  • Valet parking available for a fee
  • Take a swim in the indoor pool
  • Services include dry cleaning/laundry, a concierge and luggage storage
  • On-site recreation includes a gym and a steam room
  • Guests have great things to say about the helpful staff and the clean guestrooms
  • Within a 10-minute walk of City Museum and Enterprise Center
  • Dogs welcome for a fee
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness centre. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business centre and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

For a fee, guests can enjoy a cooked-to-order breakfast daily from 6:30 AM to 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
    • Service animals are exempt from fees.

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cots (infant beds) are not available.

Payment types at the property

Important information

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
Front desk staff will greet guests on arrival at the property.
If you cancel your booking, you'll be subject to the host's cancellation policy. In accordance with EU regulations about consumer rights, property booking services are not subject to the right of withdrawal.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness
Rating 10 - Excellent. 1024 out of 1422 reviews
Rating 8 - Good. 209 out of 1422 reviews
Rating 6 - Okay. 93 out of 1422 reviews
Rating 4 - Poor. 43 out of 1422 reviews
Rating 2 - Terrible. 53 out of 1422 reviews

Reviews

10/10 Excellent

Julie

Business traveller, Travelled with partner
Liked: Amenities
Everything about this hotel was magical! Food is fove star service people rooms. Saunna workout room and it's beautiful!
Stayed 2 nights in Jul 2025

10/10 Excellent

Rebecca

Travelled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Kevin was especially helpful and good to find a fellow LFC supporter !
Stayed 2 nights in Jul 2025

10/10 Excellent

Michael

Stayed 1 night in Jul 2025

10/10 Excellent

Lindsay

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Jul 2025

6/10 Okay

Randy

Stayed 3 nights in Jul 2025

10/10 Excellent

Lynne

Travelled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

10/10 Excellent

rebecca

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was a great location
Stayed 1 night in Jun 2025

10/10 Excellent

Shauna

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Jun 2025

10/10 Excellent

Nicole, The Woodlands

Travelled with family, Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This hotel was absolutely beautiful and so unique. The staff was so amazing and friendly, and the rooms were beautiful. We will definitely be repeat guests.
Stayed 3 nights in Jul 2025

10/10 Excellent

Audra

Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location, nice restaurant in the hotel. Friendly staff
Stayed 2 nights in Jun 2025

8/10 Good

David

Stayed 1 night in Jul 2025

10/10 Excellent

Krystal

Stayed 4 nights in Jul 2025

10/10 Excellent

Verified traveller

Travelled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jun 2025

8/10 Good

Holly

Liked: Staff & service, property conditions & facilities
Stayed 3 nights in Jul 2025

10/10 Excellent

Carrie

Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
What a cool place this is! Off the charts! Beautiful comfy corner room - friendly staff- gorgeous and provocative art gallery open 24/7 - pool sauna steam - food drink wine coffee- eclectic neighborhood- what else could one wish for? Xo
Stayed 1 night in Jul 2025

10/10 Excellent

daniel

Stayed 1 night in Jul 2025

10/10 Excellent

Olga Janeth

Liked: Cleanliness, amenities, property conditions & facilities
Stayed 3 nights in Jul 2025

6/10 Okay

H

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
We were told it was unsafe to use their valet parking because it’s outside. There were also some strange tiles at the pool with symbols that looked like swastikas. Everything else was pretty good.
Stayed 1 night in Jun 2025

6/10 Okay

diane lemboula, olney

Liked: Amenities
Disliked: Staff & service
There were homeless outside of the propoerty; there were no assistance in carrying the luggages. Room service brought food uncovered from the kitchen to the 5th floor room, this was very unsafe and unclean. The bathroom did not look clean at all.
Lobby Entrance
view from my windown
Stayed 3 nights in Jul 2025

2/10 Terrible

Shanzaib

Business traveller
Disliked: Cleanliness, amenities, property conditions & facilities
Worst hotel and staff ever
Stayed 5 nights in Jul 2025

6/10 Okay

Jamie

Travelled with family
Disliked: Cleanliness, staff & service

Disappointed

I had such high hopes for this hotel! It was mostly disappointing. The unpleasant experience started off with a phone call from the hotel at 3:30pm telling me they were switching our family of four to a bunk room - room with one double bed on bottom/twin bed on top. I kindly explained that would not work and that we had booked a luxury double queen 3 months ago and had already paid in full. They said okay and hung up. At check-in (they were not friendly or welcoming whatsoever), I asked about the room to confirm it was a double queen and they said they had us in a bunk room. We had to talk through the whole process again. They did not apologize or show any sort of concern for the situation. Then we get to our room and it’s GROSS. Hairs on the food, poop stains in the toilet, water/toothpaste stains on the sink mirror, no toilet paper, dental floss in the trash, etc. We were trying to get to the Cards game so I went back to the nicely share details of the room. They said they would clean it. Again, no apologies for the inconvenience. We came back at 11ish to a mildly better room, but at this point, were too tired to fuss. Notes: Valet is $50. I asked the lady at check-in if there were other options. She said there was self parking for $20 every 12 hours. It was only $27 for 24 hours so a much better option than valet. ;) Positive notes - coffee in the cafe was good! Decor is fun. We typically stay in the best hotels but this one missed the mark for us.
Stayed 1 night in Jul 2025

10/10 Excellent

Najah

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Good stay
Stayed 1 night in Jun 2025

10/10 Excellent

Shamiyer

I loved my stay the room was perfect and very comfortable and clean
Stayed 1 night in Jul 2025

10/10 Excellent

G

Stayed 3 nights in May 2025

10/10 Excellent

Mike

Travelled with partner
Liked: Amenities
Museum is fabulous, lobby and room are terrific!
Stayed 1 night in Jul 2025