Cheap flights from Defiance

Many airlines offer flexible change policies

Earn BONUS+ rewards on top of your airline points

Enjoy exclusive promotions on the ebookers app!

Defiance Flight Information
Origin airport IATA code
STL

Your cheap flight from Defiance is available right now.

Visit us now at Ebookers to choose from lots of cheap flights leaving Defiance or our last minute air tickets from Defiance at unbeatable prices, specially chosen for those who want the best deal possible. Ebookers continuously compares and updates the choice of air tickets available from Defiance, offered by more than 400 airlines worldwide. Ebookers works 24/7 to find the best deals so that our clients don’t have to waste their valuable time. Wherever you are going, you will find your perfect combination for a fantastic holiday at a budget price right here with our extensive flights database and helpful information; star ratings, reviews, maps and more… Many discount flights with a departure from Defiance and last minute flights from Defiance are available at Ebookers to help you organise your flights the way you want them at a price you can afford. Come and prepare your perfect holiday now at Ebookers.

Fancy a break from Defiance? Book your flight in advance from Defiance!

Thinking about getting away for a while and leaving from Defiance? Visit Ebookers and discover our selection of inexpensive Defiance flights and air tickets from Defiance at unbelievable prices with a great choice of airlines - over 400 in fact. We give excellent service at an affordable price. For a great weekend away from Defiance, visit to Ebookers where we have many available flights departing Defiance on special offer. Check out our deals and find a flight leaving Defiance at a price you never imagined. These special Ebookers offers aren’t just about cheap flights. We have over 95,000 hotels worldwide in our database, so why not stay in a Defiance hotel and start or end your break in style? Combine your choice of flight, hotel and car rental from our vast, reliable database to create your perfect holiday or dream weekend at a discounted price with Ebookers. Don’t wait or you may be too late!

Featured Hotels near Defiance

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
The price is €99 per night from 27 Jul to 28 Jul
€99
27 Jul - 28 Jul
includes taxes & fees
Our customers tell us they can't get enough of The Wildwood Hotel's great location. During your stay, you'll be within walking distance of Wildwood Dog Park. Free breakfast, free WiFi in public areas and free self-parking are available.
9.2/10 Wonderful! (1,661 reviews)
"The pool steps were extremely slippery and not level. My son and I slipped going into the pool. Plus the railing into the pool was loose. The free breakfast was pretty weak. The only warm items they had, you to heat up yourself. The property was clean and the room was nice. Great water pressure but ..."

Reviewed on 1 Jul 2026

Opens in a new windowThe Wildwood Hotel
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
The price is €138 per night from 5 Jul to 6 Jul
€138
5 Jul - 6 Jul
includes taxes & fees
Our customers tell us they can't get enough of Hilton St. Louis Frontenac's great location. During your stay, you'll be close to Saint Louis Galleria Mall. You'll find features such as free WiFi in public areas, free self-parking and a free round-trip airport shuttle.
8.8/10 Excellent! (1,000 reviews)
"It's a classic hotel in a great location. The front desk staff aren't the most enthusiastic—they do their job, but don't really go the extra mile to help guests. The hotel is a bit dated, but it's clean, and that's what matters most. I don't think the breakfast is worth the price, as it's very basic. ..."

Reviewed on 30 Jun 2026

Opens in a new windowHilton St. Louis Frontenac
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is €119 per night from 7 Jul to 8 Jul
€119
7 Jul - 8 Jul
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Hollywood Casino & Hotel St. Louis. During your stay, you're just a quick walk from Hollywood Casino. Features include free self-parking and a free round-trip airport shuttle, plus 7 restaurants.
8.6/10 Excellent! (2,207 reviews)
"Overall stay was good. Housekeeping wasn’t bad but could have been better. Dirty along side furniture and corners underneath the desk. A stack of towels and a garbage bag was stacked on the desk along with an extra pillow but the dirty towels and trash was left. Everything else was good."

Reviewed on 30 Jun 2026

Opens in a new windowHollywood Casino & Hotel St. Louis
Save an average of 15% on thousands of hotels when you're signed in
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
The price is €166 per night from 20 Jul to 21 Jul
€166
20 Jul - 21 Jul
includes taxes & fees
Our customers tell us that they enjoy the overall property condition at Ameristar Casino Resort and Spa. During your stay, you're just a quick walk from Ameristar Casino St. Charles. 6 restaurants, 2 bars and a full-service spa are available.
8.6/10 Excellent! (1,001 reviews)
"The check in person was friendly and efficient. Our room was wonderful and clean. The rooms are very large."

Reviewed on 1 Jul 2026

Opens in a new windowAmeristar Casino Resort and Spa
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
The price is €95 per night from 2 Jul to 3 Jul
€95
2 Jul - 3 Jul
includes taxes & fees
The free breakfast at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham gets high marks from our customers. During your stay, you'll be within walking distance of SSM Health St. Clare Hospital - Fenton. Free WiFi in public areas, free self-parking and an indoor pool are available.
7.8/10 Good! (1,400 reviews)
"The floors in our room weren't thoroughly cleaned prior to our arrival. When we entered upon arrival there was no soap in the bathroom. There were also contacts on the floor under the bathroom sink/counter. In the main portion of our room, I found a cookie on the floor by the bed and chips under ..."

Reviewed on 1 Jul 2026

Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
The price is €73 per night from 9 Jul to 10 Jul
€73
9 Jul - 10 Jul
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Days Inn and Suites by Wyndham St. Louis/Westport Plaza. During your stay, you're just a quick walk from Westport Plaza. Enjoy features like free breakfast, free WiFi in public areas and free self-parking.
4.6/10 (1,008 reviews)
"ABSOLUTELY DISGUSTING."

Reviewed on 30 Jun 2026

Opens in a new windowDays Inn and Suites by Wyndham St. Louis/Westport Plaza
Don't see what you're looking for?
See all available properties in Defiance
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.