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Featured Hotels near O Brien

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien, FL
During your stay at this holiday home, you're just a quick walk from Suwannee River. You'll find features such as a gym, laundry facilities and an arcade/games room. The holiday home offers free WiFi and a kitchen.
9.8/10 Exceptional! (28 reviews)
This was an absolutely delightful house on the water. Plenty of room for the kids to run, it didn't feel sketchy with the river nearby (if you're anxious like me and worried about kids near a river, there's a decent land barrier), tons of stuff to do at the house and nearby, gorgeous area and great ...

Reviewed on 12 Oct 2025

Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
MARGARITAVILLE SUWANNEE RIVER

MARGARITAVILLE SUWANNEE RIVER

O'Brien, FL
During your stay at this holiday home, you're just a quick walk from Suwannee River. Enjoy features like laundry facilities and an arcade/games room. The holiday home offers a kitchen and 3 bathrooms.
9.4/10 Exceptional! (59 reviews)
A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!

Reviewed on 1 Sept 2025

Opens in a new windowMARGARITAVILLE SUWANNEE RIVER
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
The price is €123 per night from 30 Nov to 1 Dec
€123
30 Nov - 1 Dec
includes taxes & fees
The free breakfast at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG gets high marks from our customers. During your stay, you'll be close to Alachua Sports Complex. You'll find features such as free WiFi in public areas and free self-parking, plus an outdoor pool.
9.4/10 Exceptional! (1,011 reviews)
Everything great

Reviewed on 11 Nov 2025

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
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Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
The price is €79 per night from 1 Dec to 2 Dec
€79
1 Dec - 2 Dec
includes taxes & fees
The free breakfast at Best Western Plus Lake City gets good marks from our customers. During your stay, you'll be within walking distance of Lake City Mall. You'll find features such as free WiFi in public areas and free self-parking, plus an indoor pool.
9/10 Wonderful! (1,055 reviews)
Clean room, friendly staff

Reviewed on 5 Nov 2025

Opens in a new windowBest Western Plus Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
The price is €91 per night from 1 Dec to 2 Dec
€91
1 Dec - 2 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the free breakfast at La Quinta Inn & Suite by Wyndham Lake City. During your stay, you're just a quick walk from Fresenius Medical Care at Lake City Medical Center. You'll find features such as free WiFi in public areas and free self-parking, plus an indoor pool.
8.6/10 Excellent! (1,011 reviews)
I missed breakfast, plenty of parking and I did feel safe. The room seemed clean but did notice crumbs probably from chips on the floor by the couch like the vacuum must have missed them or was done quickly. I was excited that it had a microwave as it seems hotels are getting rid of those in rooms. ...

Reviewed on 12 Nov 2025

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129, Live Oak, FL
The price is €123 per night from 18 Nov to 19 Nov
€123
18 Nov - 19 Nov
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Holiday Inn Express & Suites Live Oak by IHG. During your stay, you'll be close to Suwannee County Historical Museum. Features include free breakfast, free WiFi in public areas and free self-parking.
8.2/10 Very Good! (762 reviews)
Yes

Reviewed on 11 Nov 2025

Opens in a new windowHoliday Inn Express & Suites Live Oak by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.