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Featured Hotels near O Brien

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien, FL
During your stay at this holiday home, you're just a quick walk from Suwannee River. You'll find features such as a gym, laundry facilities and an arcade/games room. The holiday home offers free WiFi and a kitchen.
9.8/10 Exceptional! (28 reviews)
This was an absolutely delightful house on the water. Plenty of room for the kids to run, it didn't feel sketchy with the river nearby (if you're anxious like me and worried about kids near a river, there's a decent land barrier), tons of stuff to do at the house and nearby, gorgeous area and great ...

Reviewed on 12 Oct 2025

Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
The price is €119 per night from 11 Nov to 12 Nov
€119
11 Nov - 12 Nov
includes taxes & fees
The free breakfast at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG gets high marks from our customers. During your stay, you'll be close to Alachua Sports Complex. You'll find features such as free WiFi in public areas and free self-parking, plus an outdoor pool.
9.4/10 Exceptional! (1,000 reviews)
Best hotel in the area. Everything was clean and functional. The staff was very welcoming and friendly, and accommodating. Will definitely return.

Reviewed on 29 Oct 2025

Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
The price is €81 per night from 16 Nov to 17 Nov
€81
16 Nov - 17 Nov
includes taxes & fees
The free breakfast at Best Western Plus Lake City gets good marks from our customers. During your stay, you'll be within walking distance of Lake City Mall. You'll find features such as free WiFi in public areas and free self-parking, plus an indoor pool.
9/10 Wonderful! (1,055 reviews)
Clean room, friendly staff

Reviewed on 5 Nov 2025

Opens in a new windowBest Western Plus Lake City
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Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court, Lake City, FL
The price is €85 per night from 16 Nov to 17 Nov
€85
16 Nov - 17 Nov
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Tru by Hilton Lake City. During your stay, you'll be within walking distance of Fresenius Medical Care at Lake City Medical Center. Free breakfast, free WiFi in public areas and free self-parking are available.
9/10 Wonderful! (1,015 reviews)
The room was spotless, very comfy bed, pillow and linens. I've been having issues with my knee, so nice to get a tub to relax in!

Reviewed on 31 Oct 2025

Opens in a new windowTru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE, Lake City, FL
The price is €91 per night from 1 Dec to 2 Dec
€91
1 Dec - 2 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the free breakfast at La Quinta Inn & Suite by Wyndham Lake City. During your stay, you're just a quick walk from Fresenius Medical Care at Lake City Medical Center. You'll find features such as free WiFi in public areas and free self-parking, plus an indoor pool.
8.6/10 Excellent! (1,007 reviews)
Check in was an extremely easy process with the pre-check in link. Friendly courteous staff. Room was clean and comfortable. Will definitely stay in the future

Reviewed on 2 Nov 2025

Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129, Live Oak, FL
The price is €121 per night from 9 Nov to 10 Nov
€121
9 Nov - 10 Nov
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Holiday Inn Express & Suites Live Oak by IHG. During your stay, you'll be close to Suwannee County Historical Museum. Features include free breakfast, free WiFi in public areas and free self-parking.
8.2/10 Very Good! (760 reviews)
Could do with touch up on details like paint and corking and grout tiles in bathrooms. For the price your paying. Plus did not like the tv locked for direct tv only, so cant steam your phone to the tv model has, but hotel locked the option

Reviewed on 4 Nov 2025

Opens in a new windowHoliday Inn Express & Suites Live Oak by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.